Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

Oxidized dGTP (8-oxo-7,8-dihydro-2´-deoxyguanosine triphosphate, 8-oxodGTP) insertion by DNA polymerases strongly promotes cancer and human disease. How DNA polymerases discriminate against oxidized and undamaged nucleotides, especially in error-prone double strand break (DSB) repair, is poorly unde...

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Detalles Bibliográficos
Autores principales: Jamsen, Joonas A., Sassa, Akira, Shock, David D., Beard, William A., Wilson, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024293/
https://www.ncbi.nlm.nih.gov/pubmed/33824325
http://dx.doi.org/10.1038/s41467-021-21354-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024293/
https://www.ncbi.nlm.nih.gov/pubmed/33824325
http://dx.doi.org/10.1038/s41467-021-21354-6

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