MLL5 improves ATRA driven differentiation and promotes xenotransplant engraftment in acute promyelocytic leukemia model

Although the mixed lineage leukemia 5 (MLL5) gene has prognostic implications in acute promyelocyte leukemia (APL), the underlying mechanism remains to be elucidated. Here, we demonstrate the critical role exerted by MLL5 in APL regarding cell proliferation and resistance to drug-induced apoptosis,...

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Detalles Bibliográficos
Autores principales: Pereira-Martins, Diego A., Weinhäuser, Isabel, Coelho-Silva, Juan Luiz, França-Neto, Pedro L., Almeida, Luciana Y., Bianco, Thiago M., Silva, Cleide L., França, Rafael F., Traina, Fabiola, Rego, Eduardo M., Schuringa, Jan Jacob, Lucena-Araujo, Antonio R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024355/
https://www.ncbi.nlm.nih.gov/pubmed/33824267
http://dx.doi.org/10.1038/s41419-021-03604-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024355/
https://www.ncbi.nlm.nih.gov/pubmed/33824267
http://dx.doi.org/10.1038/s41419-021-03604-z

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