Rational thermostabilisation of four-helix bundle dimeric de novo proteins

The stability of proteins is an important factor for industrial and medical applications. Improving protein stability is one of the main subjects in protein engineering. In a previous study, we improved the stability of a four-helix bundle dimeric de novo protein (WA20) by five mutations. The stabil...

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Detalles Bibliográficos
Autores principales: Irumagawa, Shin, Kobayashi, Kaito, Saito, Yutaka, Miyata, Takeshi, Umetsu, Mitsuo, Kameda, Tomoshi, Arai, Ryoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024369/
https://www.ncbi.nlm.nih.gov/pubmed/33824364
http://dx.doi.org/10.1038/s41598-021-86952-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024369/
https://www.ncbi.nlm.nih.gov/pubmed/33824364
http://dx.doi.org/10.1038/s41598-021-86952-2

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