Engineered AAV8 capsid acquires heparin and AVB sepharose binding capacity but has altered in vivo transduction efficiency

Naturally occurring adeno-associated virus (AAV) serotypes that bind to ligands such as AVB sepharose or heparin can be purified by affinity chromatography, which is a more efficient and scalable method than gradient ultracentrifugation. Wild type AAV8 does not bind effectively to either of these mo...

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Detalles Bibliográficos
Autores principales: van Lieshout, Laura P., Stegelmeier, Ashley A., Rindler, Tara N., Lawder, John J., Sorensen, Debra L., Frost, Kathy L., Booth, Stephanie A., Bridges, James P., Wootton, Sarah K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024426/
https://www.ncbi.nlm.nih.gov/pubmed/33028973
http://dx.doi.org/10.1038/s41434-020-00198-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024426/
https://www.ncbi.nlm.nih.gov/pubmed/33028973
http://dx.doi.org/10.1038/s41434-020-00198-7

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