DFT and molecular dynamics studies of astaxanthin-metal ions (Cu(2+) and Zn(2+)) complex to prevent glycated human serum albumin from possible unfolding

Glycated human serum albumin (gHSA) undergoes conformational changes of proteins caused by free radicals. The glycation process results in a reduced ability of albumin as an endogenous scavenger in diabetes mellitus type 2 (T2DM) patients. Astaxanthin (ASX) has been shown to prevent gHSA from experi...

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Detalles Bibliográficos
Autores principales: Wibowo, Syahputra, Widyarti, Sri, Sabarudin, Akhmad, Soeatmadji, Djoko Wahono, Sumitro, Sutiman Bambang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024611/
https://www.ncbi.nlm.nih.gov/pubmed/33851048
http://dx.doi.org/10.1016/j.heliyon.2021.e06548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024611/
https://www.ncbi.nlm.nih.gov/pubmed/33851048
http://dx.doi.org/10.1016/j.heliyon.2021.e06548

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