A cancer‐associated CDKN1B mutation induces p27 phosphorylation on a novel residue: a new mechanism for tumor suppressor loss‐of‐function

CDKN1B haploinsufficiency promotes the development of several human cancers. The gene encodes p27(Kip1), a protein playing pivotal roles in the control of growth, differentiation, cytoskeleton dynamics, and cytokinesis. CDKN1B haploinsufficiency has been associated with chromosomal or gene aberratio...

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Detalles Bibliográficos
Autores principales: Bencivenga, Debora, Stampone, Emanuela, Aulitto, Arianna, Tramontano, Annunziata, Barone, Clementina, Negri, Aide, Roberti, Domenico, Perrotta, Silverio, Della Ragione, Fulvio, Borriello, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024736/
https://www.ncbi.nlm.nih.gov/pubmed/33316141
http://dx.doi.org/10.1002/1878-0261.12881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024736/
https://www.ncbi.nlm.nih.gov/pubmed/33316141
http://dx.doi.org/10.1002/1878-0261.12881

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