Age-related loss of axonal regeneration is reflected by the level of local translation

Regeneration capacity is reduced as CNS axons mature. Using laser-mediated axotomy, proteomics and puromycin-based tagging of newly-synthesized proteins in a human embryonic stem cell-derived neuron culture system that allows isolation of axons from cell bodies, we show here that efficient regenerat...

Descripción completa

Detalles Bibliográficos
Autores principales: van Erp, Susan, van Berkel, Annemiek A., Feenstra, Eline M., Sahoo, Pabitra K., Wagstaff, Laura J., Twiss, Jeffery L., Fawcett, James W., Eva, Richard, ffrench-Constant, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024785/
https://www.ncbi.nlm.nih.gov/pubmed/33450233
http://dx.doi.org/10.1016/j.expneurol.2020.113594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024785/
https://www.ncbi.nlm.nih.gov/pubmed/33450233
http://dx.doi.org/10.1016/j.expneurol.2020.113594

Ejemplares similares