Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis

Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms (MPNs) are incompletely understood. We aimed to generate a comprehensive map of the stroma in MPNs/MFs on a single-cell level in murine m...

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Detalles Bibliográficos
Autores principales: Leimkühler, Nils B., Gleitz, Hélène F.E., Ronghui, Li, Snoeren, Inge A.M., Fuchs, Stijn N.R., Nagai, James S., Banjanin, Bella, Lam, King H., Vogl, Thomas, Kuppe, Christoph, Stalmann, Ursula S.A., Büsche, Guntram, Kreipe, Hans, Gütgemann, Ines, Krebs, Philippe, Banz, Yara, Boor, Peter, Tai, Evelyn Wing-Yin, Brümmendorf, Tim H., Koschmieder, Steffen, Crysandt, Martina, Bindels, Eric, Kramann, Rafael, Costa, Ivan G., Schneider, Rebekka K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024900/
https://www.ncbi.nlm.nih.gov/pubmed/33301706
http://dx.doi.org/10.1016/j.stem.2020.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024900/
https://www.ncbi.nlm.nih.gov/pubmed/33301706
http://dx.doi.org/10.1016/j.stem.2020.11.004

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