Enzymatic bypass of an N(6)-deoxyadenosine DNA–ethylene dibromide–peptide cross-link by translesion DNA polymerases

Unrepaired DNA–protein cross-links, due to their bulky nature, can stall replication forks and result in genome instability. Large DNA–protein cross-links can be cleaved into DNA–peptide cross-links, but the extent to which these smaller fragments disrupt normal replication is not clear. Ethylene di...

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Detalles Bibliográficos
Autores principales: Ghodke, Pratibha P., Gonzalez-Vasquez, Gabriela, Wang, Hui, Johnson, Kevin M., Sedgeman, Carl A., Guengerich, F. Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024977/
https://www.ncbi.nlm.nih.gov/pubmed/33617883
http://dx.doi.org/10.1016/j.jbc.2021.100444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024977/
https://www.ncbi.nlm.nih.gov/pubmed/33617883
http://dx.doi.org/10.1016/j.jbc.2021.100444

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