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Enzymatic bypass of an N(6)-deoxyadenosine DNA–ethylene dibromide–peptide cross-link by translesion DNA polymerases
Unrepaired DNA–protein cross-links, due to their bulky nature, can stall replication forks and result in genome instability. Large DNA–protein cross-links can be cleaved into DNA–peptide cross-links, but the extent to which these smaller fragments disrupt normal replication is not clear. Ethylene di...
Autores principales: | Ghodke, Pratibha P., Gonzalez-Vasquez, Gabriela, Wang, Hui, Johnson, Kevin M., Sedgeman, Carl A., Guengerich, F. Peter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024977/ https://www.ncbi.nlm.nih.gov/pubmed/33617883 http://dx.doi.org/10.1016/j.jbc.2021.100444 |
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