Insert L1 is a central hub for allosteric regulation of USP1 activity

During DNA replication, the deubiquitinating enzyme USP1 limits the recruitment of translesion polymerases by removing ubiquitin marks from PCNA to allow specific regulation of the translesion synthesis (TLS) pathway. USP1 activity depends on an allosteric activator, UAF1, and this is tightly contro...

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Detalles Bibliográficos
Autores principales: Dharadhar, Shreya, van Dijk, Willem J, Scheffers, Serge, Fish, Alexander, Sixma, Titia K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024992/
https://www.ncbi.nlm.nih.gov/pubmed/33619839
http://dx.doi.org/10.15252/embr.202051749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024992/
https://www.ncbi.nlm.nih.gov/pubmed/33619839
http://dx.doi.org/10.15252/embr.202051749

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