PRIMA-1(met) induces autophagy in colorectal cancer cells through upregulation of the mTOR/AMPK-ULK1-Vps34 signaling cascade

p53-reactivation and induction of massive apoptosis-1, APR-017 methylated (PRIMA-1(met); APR246) targets mutant p53 to restore its wild-type structure and function. It was previously demonstrated that PRIMA-1(met) effectively inhibited the growth of colorectal cancer (CRC) cells in a p53-independent...

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Detalles Bibliográficos
Autores principales: Li, Xiao-Lan, Zhou, Jianbiao, Xia, Chen-Jing, Min, Han, Lu, Zhong-Kai, Chen, Zhi-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025076/
https://www.ncbi.nlm.nih.gov/pubmed/33846805
http://dx.doi.org/10.3892/or.2021.8037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025076/
https://www.ncbi.nlm.nih.gov/pubmed/33846805
http://dx.doi.org/10.3892/or.2021.8037

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