Cargando…

PRIMA-1(met) induces autophagy in colorectal cancer cells through upregulation of the mTOR/AMPK-ULK1-Vps34 signaling cascade

p53-reactivation and induction of massive apoptosis-1, APR-017 methylated (PRIMA-1(met); APR246) targets mutant p53 to restore its wild-type structure and function. It was previously demonstrated that PRIMA-1(met) effectively inhibited the growth of colorectal cancer (CRC) cells in a p53-independent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiao-Lan, Zhou, Jianbiao, Xia, Chen-Jing, Min, Han, Lu, Zhong-Kai, Chen, Zhi-Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025076/ https://www.ncbi.nlm.nih.gov/pubmed/33846805 http://dx.doi.org/10.3892/or.2021.8037

Ejemplares similares

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
por: Wang, Jiwei, et al.
Publicado: (2016)

Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy
por: Mercer, Thomas John, et al.
Publicado: (2021)

Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway
por: Yuan, Jie, et al.
Publicado: (2018)

AMPK/Ulk1-dependent autophagy as a key mTOR regulator in the context of cell pluripotency
por: Suvorova, Irina I., et al.
Publicado: (2019)

ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase
por: Russell, Ryan C., et al.
Publicado: (2013)

Rapamycin Upregulates Autophagy by Inhibiting the mTOR-ULK1 Pathway, Resulting in Reduced Podocyte Injury
por: Wu, Lingling, et al.
Publicado: (2013)

Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways
por: Chen, Ting, et al.
Publicado: (2023)

Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway
por: Gui, Di, et al.
Publicado: (2017)

AMPK/mTOR/ULK1 Axis-Mediated Pathway Participates in Apoptosis and Autophagy Induction by Oridonin in Colon Cancer DLD-1 Cells
por: Bu, Heqi, et al.
Publicado: (2020)

Apelin-13 Protects Dopaminergic Neurons against Rotenone—Induced Neurotoxicity through the AMPK/mTOR/ULK-1 Mediated Autophagy Activation
por: Chen, Peng, et al.
Publicado: (2020)

ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation
por: Jia, Mengshu, et al.
Publicado: (2023)

Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway
por: Zheng, Jie, et al.
Publicado: (2021)

Berberine Attenuates IL-1β-Induced Damage of Nucleus Pulposus Cells via Activating the AMPK/mTOR/Ulk1 Pathway
por: Huang, Liaoyuan, et al.
Publicado: (2022)

The Association of AMPK with ULK1 Regulates Autophagy
por: Lee, Jong Woo, et al.
Publicado: (2010)

Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
por: Zhang, Yan, et al.
Publicado: (2021)

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway
por: Wang, Jin-Feng, et al.
Publicado: (2018)

AMPK-mTOR-ULK1-mediated autophagy protects carbon tetrachloride-induced acute hepatic failure by inhibiting p21 in rats
por: Wang, Qiwen, et al.
Publicado: (2021)

Antioxidant Compound, Oxyresveratrol, Inhibits APP Production through the AMPK/ULK1/mTOR-Mediated Autophagy Pathway in Mouse Cortical Astrocytes
por: Rahman, Md. Ataur, et al.
Publicado: (2021)

SPAG6 silencing induces autophagic cell death in SKM-1 cells via the AMPK/mTOR/ULK1 signaling pathway
por: Zhang, Meng, et al.
Publicado: (2020)

mTOR activates the VPS34–UVRAG complex to regulate autolysosomal tubulation and cell survival
por: Munson, Michael J, et al.
Publicado: (2015)

Late Exercise Preconditioning Promotes Autophagy against Exhaustive Exercise-Induced Myocardial Injury through the Activation of the AMPK-mTOR-ULK1 Pathway
por: Liu, Hong-Tao, et al.
Publicado: (2019)

Deciphering the Mechanism of Bushen Huoxue Decotion on Decidualization by Intervening Autophagy via AMPK/mTOR/ULK1: A Novel Discovery for URSA Treatment
por: Zhao, Xiaoxuan, et al.
Publicado: (2022)

Guanylate-Binding protein 2b regulates the AMPK/mTOR/ULK1 signalling pathway to induce autophagy during Mycobacterium bovis infection
por: Yu, Youli, et al.
Publicado: (2022)

The mTOR/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles
por: Ruolan, Wang, et al.
Publicado: (2020)

Activating autophagy and ferroptosis of 3‑Chloropropane‑1,2‑diol induces injury of human umbilical vein endothelial cells via AMPK/mTOR/ULK1
por: Yi, Xin, et al.
Publicado: (2023)

A novel danshensu/tetramethypyrazine derivative attenuates oxidative stress-induced autophagy injury via the AMPK-mTOR-Ulk1 signaling pathway in cardiomyocytes
por: Xie, Caipeng, et al.
Publicado: (2021)

Camptothecin Inhibits Neddylation to Activate the Protective Autophagy Through NF-κB/AMPK/mTOR/ULK1 Axis in Human Esophageal Cancer Cells
por: Heng, Yongqing, et al.
Publicado: (2021)

Shabyar Ameliorates High Glucose Induced Retinal Pigment Epithelium Injury Through Suppressing Aldose Reductase and AMPK/mTOR/ULK1 Autophagy Pathway
por: Liu, Xiao Yan, et al.
Publicado: (2022)

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy
por: Petherick, Katy J., et al.
Publicado: (2015)

TNFAIP8 regulates gastric cancer growth via mTOR‐Akt‐ULK1 pathway and autophagy signals
por: Chen, Zheng, et al.
Publicado: (2021)

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
por: Dite, Toby A., et al.
Publicado: (2017)

Aurora-B knockdown inhibits osteosarcoma metastasis by inducing autophagy via the mTOR/ULK1 pathway
por: Wu, Xin, et al.
Publicado: (2020)

Echovirus induces autophagy to promote viral replication via regulating mTOR/ULK1 signaling pathway
por: Wu, Chunchen, et al.
Publicado: (2023)

PRIMA-1(met) (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms
por: Li, Xiao-Lan, et al.
Publicado: (2015)

Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway
por: Wei, X., et al.
Publicado: (2021)

Grain-sized moxibustion at Zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK/mTOR signaling pathway
por: Xu, Qian, et al.
Publicado: (2023)

Alpinetin alleviates osteoporosis by promoting osteogenic differentiation in BMSCs by triggering autophagy via PKA/mTOR/ULK1 signaling
por: Zeng, Chenying, et al.
Publicado: (2022)

Icariin alleviates osteoarthritis through PI3K/Akt/mTOR/ULK1 signaling pathway
por: Chen, Yan, et al.
Publicado: (2022)

Nutrient ingestion increased mTOR signaling, but not hVps34 activity in human skeletal muscle after sprint exercise
por: Rundqvist, Håkan C, et al.
Publicado: (2013)

Exendin-4 and Liraglutide Attenuate Glucose Toxicity-Induced Cardiac Injury through mTOR/ULK1-Dependent Autophagy
por: Yu, Wei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9lr9e8n3sgsujtjsa1lp9t25re