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DNA topoisomerase 3 is required for efficient germ cell quality control

An important quality control mechanism eliminates meiocytes that have experienced recombination failure during meiosis. The culling of defective oocytes in Caenorhabditis elegans meiosis resembles late oocyte elimination in female mammals. Here we show that topoisomerase 3 depletion generates DNA le...

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Detalles Bibliográficos
Autores principales: Dello Stritto, Maria Rosaria, Bauer, Bernd, Barraud, Pierre, Jantsch, Verena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025215/
https://www.ncbi.nlm.nih.gov/pubmed/33798260
http://dx.doi.org/10.1083/jcb.202012057