Coupling of Cdc20 inhibition and activation by BubR1

Tight regulation of the APC/C-Cdc20 ubiquitin ligase that targets cyclin B1 for degradation is important for mitotic fidelity. The spindle assembly checkpoint (SAC) inhibits Cdc20 through the mitotic checkpoint complex (MCC). In addition, phosphorylation of Cdc20 by cyclin B1–Cdk1 independently inhi...

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Detalles Bibliográficos
Autores principales: Hein, Jamin B., Garvanska, Dimitriya H., Nasa, Isha, Kettenbach, Arminja N., Nilsson, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025235/
https://www.ncbi.nlm.nih.gov/pubmed/33819340
http://dx.doi.org/10.1083/jcb.202012081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025235/
https://www.ncbi.nlm.nih.gov/pubmed/33819340
http://dx.doi.org/10.1083/jcb.202012081

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