Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues

Metformin is the primary drug for type 2 diabetes treatment and a promising candidate for other disease treatment. It has significant deviations between individuals in therapy efficiency and pharmacokinetics, leading to the administration of an unnecessary overdose or an insufficient dose. There is...

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Detalles Bibliográficos
Autores principales: Zake, Darta Maija, Kurlovics, Janis, Zaharenko, Linda, Komasilovs, Vitalijs, Klovins, Janis, Stalidzans, Egils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026019/
https://www.ncbi.nlm.nih.gov/pubmed/33826656
http://dx.doi.org/10.1371/journal.pone.0249594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026019/
https://www.ncbi.nlm.nih.gov/pubmed/33826656
http://dx.doi.org/10.1371/journal.pone.0249594

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