Cargando…

GABA transporter sustains IL-1β production in macrophages

Accumulating evidence shows that nervous system governs host immune responses; however, how γ-aminobutyric acid (GABA)ergic system shapes the function of innate immune cells is poorly defined. Here, we demonstrate that GABA transporter (GAT2) modulates the macrophage function. GAT2 deficiency lowers...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Yaoyao, He, Fang, Wu, Xiaoyan, Tan, Bie, Chen, Siyuan, Liao, Yuexia, Qi, Ming, Chen, Shuai, Peng, Yuanyi, Yin, Yulong, Ren, Wenkai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026138/ https://www.ncbi.nlm.nih.gov/pubmed/33827820 http://dx.doi.org/10.1126/sciadv.abe9274

Ejemplares similares

Serine Supports IL-1β Production in Macrophages Through mTOR Signaling
por: Chen, Siyuan, et al.
Publicado: (2020)

Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes
por: Ren, Wenkai, et al.
Publicado: (2019)

Amino-acid transporters in T-cell activation and differentiation
por: Ren, Wenkai, et al.
Publicado: (2017)

Melatonergic signalling instructs transcriptional inhibition of IFNGR2 to lessen interleukin‐1β‐dependent inflammation
por: Xia, Yaoyao, et al.
Publicado: (2022)

Intestinal Microbiota-Derived GABA Mediates Interleukin-17 Expression during Enterotoxigenic Escherichia coli Infection
por: Ren, Wenkai, et al.
Publicado: (2017)

Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages
por: Wang, Hao, et al.
Publicado: (2021)

GABA signaling enforces intestinal germinal center B cell differentiation
por: Liao, Yuexia, et al.
Publicado: (2022)

Betaine Inhibits Interleukin-1β Production and Release: Potential Mechanisms
por: Xia, Yaoyao, et al.
Publicado: (2018)

Proteome analysis for the global proteins in the jejunum tissues of enterotoxigenic Escherichia coli -infected piglets
por: Ren, Wenkai, et al.
Publicado: (2016)

Glutamine-Induced Secretion of Intestinal Secretory Immunoglobulin A: A Mechanistic Perspective
por: Ren, Wenkai, et al.
Publicado: (2016)

Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17
por: Ren, Wenkai, et al.
Publicado: (2016)

Glutamine supplementation improves intestinal cell proliferation and stem cell differentiation in weanling mice
por: Chen, Siyuan, et al.
Publicado: (2018)

Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen
por: Ren, Wenkai, et al.
Publicado: (2018)

Draft Genome Sequence of Enterotoxigenic Escherichia coli Strain W25K
por: Ren, Wenkai, et al.
Publicado: (2014)

Ironing Out the Details: How Iron Orchestrates Macrophage Polarization
por: Xia, Yaoyao, et al.
Publicado: (2021)

B cell-derived GABA elicits IL-10(+) macrophages to limit anti-tumour immunity
por: Zhang, Baihao, et al.
Publicado: (2021)

GABA and Glutamate Transporters in Brain
por: Zhou, Yun, et al.
Publicado: (2013)

Anion transport and GABA signaling
por: Hübner, Christian A., et al.
Publicado: (2013)

The application of antimicrobial peptides as growth and health promoters for swine
por: Xiao, Hao, et al.
Publicado: (2015)

Exploring polyamines: Functions in embryo/fetal development
por: Hussain, Tarique, et al.
Publicado: (2017)

Effects of Lactococcus lactis on the Intestinal Functions in Weaning Piglets
por: Yu, Dongming, et al.
Publicado: (2021)

Structure, function, and plasticity of GABA transporters
por: Scimemi, Annalisa
Publicado: (2014)

Reconstitution of GABA, Glycine and Glutamate Transporters
por: Danbolt, Niels Christian, et al.
Publicado: (2021)

Characteristic Expressions of GABA Receptors and GABA Producing/Transporting Molecules in Rat Kidney
por: Takano, Kozue, et al.
Publicado: (2014)

Alpha-ketoglutarate (AKG) lowers body weight and affects intestinal innate immunity through influencing intestinal microbiota
por: Chen, Shuai, et al.
Publicado: (2017)

Implication of G Protein-Coupled Receptor 43 in Intestinal Inflammation: A Mini-Review
por: Yang, Guan, et al.
Publicado: (2018)

A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus
por: Kersanté, Flavie, et al.
Publicado: (2013)

Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities
por: Wu, Xiaoyan, et al.
Publicado: (2021)

Dietary Glutamate Supplementation Ameliorates Mycotoxin-Induced Abnormalities in the Intestinal Structure and Expression of Amino Acid Transporters in Young Pigs
por: Duan, Jielin, et al.
Publicado: (2014)

GABA Metabolism and Transport: Effects on Synaptic Efficacy
por: Roth, Fabian C., et al.
Publicado: (2012)

Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization
por: Ren, Wenkai, et al.
Publicado: (2023)

Unexpected Effect of IL-1β on the Function of GABA(A) Receptors in Pediatric Focal Cortical Dysplasia
por: Alfano, Veronica, et al.
Publicado: (2022)

Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor
por: Pu, Lu, et al.
Publicado: (2012)

The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis
por: Ni, Zhenhong, et al.
Publicado: (2019)

Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity
por: Savtchenko, Leonid, et al.
Publicado: (2015)

Astrocytic GABA transporter activity modulates excitatory neurotransmission
por: Boddum, Kim, et al.
Publicado: (2016)

Bacteriostatic Potential of Melatonin: Therapeutic Standing and Mechanistic Insights
por: He, Fang, et al.
Publicado: (2021)

Prefrontal GABA and glutamate–glutamine levels affect sustained attention
por: Kondo, Hirohito M, et al.
Publicado: (2023)

GABA Transporter-1 Deficiency Confers Schizophrenia-Like Behavioral Phenotypes
por: Yu, Zhe, et al.
Publicado: (2013)

Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl(−) Transport
por: Khanna, Arjun, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vd64s2vf6cvlud33uf97krfdm6