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Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions
Myofibroblasts are the major cellular source of collagen, and their accumulation — via differentiation from fibroblasts and resistance to apoptosis — is a hallmark of tissue fibrosis. Clearance of myofibroblasts by dedifferentiation and restoration of apoptosis sensitivity has the potential to rever...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026183/ https://www.ncbi.nlm.nih.gov/pubmed/33561015 http://dx.doi.org/10.1172/jci.insight.144799 |