Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8(+) T cell function

The programmed death-1 (PD-1) and the PD ligand 1 (PD-L1) interaction represents a key immune checkpoint within the tumor microenvironment (TME), and PD-1 blockade has led to exciting therapeutic advances in clinical oncology. Although IFN-γ–dependent PD-L1 induction on tumor cells was initially tho...

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Detalles Bibliográficos
Autores principales: Petty, Amy J., Dai, Rui, Lapalombella, Rosa, Baiocchi, Robert A., Benson, Don M., Li, Zihai, Huang, Xiaopei, Yang, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026184/
https://www.ncbi.nlm.nih.gov/pubmed/33749663
http://dx.doi.org/10.1172/jci.insight.146707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026184/
https://www.ncbi.nlm.nih.gov/pubmed/33749663
http://dx.doi.org/10.1172/jci.insight.146707

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