Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells

X-linked neutropenia (XLN) is caused by gain-of-function mutations in the actin regulator Wiskott-Aldrich Syndrome protein (WASp). XLN patients have reduced numbers of cytotoxic cells in peripheral blood; however, their capacity to kill tumor cells remains to be determined. Here, we examined NK and...

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Detalles Bibliográficos
Autores principales: Kritikou, Joanna S., Oliveira, Mariana M.S., Record, Julien, Saeed, Mezida B., Nigam, Saket M., He, Minghui, Keszei, Marton, Wagner, Arnika K., Brauner, Hanna, Sendel, Anton, Sedimbi, Saikiran K., Rentouli, Stamatina, Lane, David P., Snapper, Scott B., Kärre, Klas, Vandenberghe, Peter, Orange, Jordan S., Westerberg, Lisa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026198/
https://www.ncbi.nlm.nih.gov/pubmed/33621210
http://dx.doi.org/10.1172/jci.insight.140273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026198/
https://www.ncbi.nlm.nih.gov/pubmed/33621210
http://dx.doi.org/10.1172/jci.insight.140273

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