tTARGIT AAVs mediate the sensitive and flexible manipulation of intersectional neuronal populations in mice

While Cre-dependent viral systems permit the manipulation of many neuron types, some cell populations cannot be targeted by a single DNA recombinase. Although the combined use of Flp and Cre recombinases can overcome this limitation, insufficient recombinase activity can reduce the efficacy of exist...

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Detalles Bibliográficos
Autores principales: Sabatini, Paul V, Wang, Jine, Rupp, Alan C, Affinati, Alison H, Flak, Jonathan N, Li, Chien, Olson, David P, Myers, Martin G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026215/
https://www.ncbi.nlm.nih.gov/pubmed/33704065
http://dx.doi.org/10.7554/eLife.66835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026215/
https://www.ncbi.nlm.nih.gov/pubmed/33704065
http://dx.doi.org/10.7554/eLife.66835

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