The Accessory Helix of Complexin Stabilizes a Partially Unzippered State of the SNARE Complex and Mediates the Complexin Clamping Function In Vivo

Spontaneous synaptic transmission is regulated by the protein complexin (Cpx). Cpx binds the SNARE complex, a coil-coiled four-helical bundle that mediates the attachment of a synaptic vesicle (SV) to the presynaptic membrane (PM). Cpx is thought to clamp spontaneous fusion events by stabilizing a p...

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Detalles Bibliográficos
Autores principales: Brady, Joshua, Vasin, Alexander, Bykhovskaia, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026252/
https://www.ncbi.nlm.nih.gov/pubmed/33692090
http://dx.doi.org/10.1523/ENEURO.0526-20.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026252/
https://www.ncbi.nlm.nih.gov/pubmed/33692090
http://dx.doi.org/10.1523/ENEURO.0526-20.2021

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