SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs

Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression, but the absorption mechanism remains unknown. Here, we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs. SIDT1-deficient mice show reduced b...

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Detalles Bibliográficos
Autores principales: Chen, Qun, Zhang, Fan, Dong, Lei, Wu, Huimin, Xu, Jie, Li, Hanqin, Wang, Jin, Zhou, Zhen, Liu, Chunyan, Wang, Yanbo, Liu, Yuyan, Lu, Liangsheng, Wang, Chen, Liu, Minghui, Chen, Xi, Wang, Cheng, Zhang, Chunni, Li, Dangsheng, Zen, Ke, Wang, Fangyu, Zhang, Qipeng, Zhang, Chen-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026584/
https://www.ncbi.nlm.nih.gov/pubmed/32801357
http://dx.doi.org/10.1038/s41422-020-0389-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026584/
https://www.ncbi.nlm.nih.gov/pubmed/32801357
http://dx.doi.org/10.1038/s41422-020-0389-3

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