PSPH promotes melanoma growth and metastasis by metabolic-deregulation–mediated transcriptional activation of NR4A1

Metabolic deregulation, a hallmark of cancer, fuels cancer cell growth and metastasis. Here, we show that phosphoserine phosphatase (PSPH), part of the serine metabolism pathway, is upregulated in patient-derived melanoma samples. PSPH knockdown using short hairpin RNAs (shRNAs) blocks melanoma tumo...

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Hlavní autoři: Rawat, Vipin, Malvi, Parmanand, Della Manna, Deborah, Yang, Eddy S., Bugide, Suresh, Zhang, Xuchen, Gupta, Romi, Wajapeyee, Narendra
Médium: Online Článek Text
Jazyk:English
Vydáno: 2021
Témata:
Article
On-line přístup:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026604/
https://www.ncbi.nlm.nih.gov/pubmed/33674745
http://dx.doi.org/10.1038/s41388-021-01683-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026604/
https://www.ncbi.nlm.nih.gov/pubmed/33674745
http://dx.doi.org/10.1038/s41388-021-01683-y

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