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PSPH promotes melanoma growth and metastasis by metabolic-deregulation–mediated transcriptional activation of NR4A1

Metabolic deregulation, a hallmark of cancer, fuels cancer cell growth and metastasis. Here, we show that phosphoserine phosphatase (PSPH), part of the serine metabolism pathway, is upregulated in patient-derived melanoma samples. PSPH knockdown using short hairpin RNAs (shRNAs) blocks melanoma tumo...

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Detalles Bibliográficos
Autores principales:	Rawat, Vipin, Malvi, Parmanand, Della Manna, Deborah, Yang, Eddy S., Bugide, Suresh, Zhang, Xuchen, Gupta, Romi, Wajapeyee, Narendra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026604/ https://www.ncbi.nlm.nih.gov/pubmed/33674745 http://dx.doi.org/10.1038/s41388-021-01683-y

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