Cargando…

Protein disulphide isomerase inhibition as a potential cancer therapeutic strategy

The protein disulphide isomerase (PDI) gene family is a large, diverse group of enzymes recognised for their roles in disulphide bond formation within the endoplasmic reticulum (ER). PDI therefore plays an important role in ER proteostasis, however, it also shows involvement in ER stress, a characte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Powell, Lauren E., Foster, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026947/ https://www.ncbi.nlm.nih.gov/pubmed/33742523 http://dx.doi.org/10.1002/cam4.3836

Ejemplares similares

Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties
por: Fessart, Delphine, et al.
Publicado: (2016)

Impairment of cell adhesion and migration by inhibition of protein disulphide isomerases in three breast cancer cell lines
por: Young, Henry S., et al.
Publicado: (2020)

Regulation of nerve growth and patterning by cell surface protein disulphide isomerase
por: Cook, Geoffrey MW, et al.
Publicado: (2020)

Reticulon1-C modulates protein disulphide isomerase function
por: Bernardoni, P, et al.
Publicado: (2013)

Mechanisms of Neuroprotection by Protein Disulphide Isomerase in Amyotrophic Lateral Sclerosis
por: Walker, Adam K., et al.
Publicado: (2011)

The Role of S-Nitrosylation and S-Glutathionylation of Protein Disulphide Isomerase in Protein Misfolding and Neurodegeneration
por: Halloran, M., et al.
Publicado: (2013)

Novel roles for protein disulphide isomerase in disease states: a double edged sword?
por: Parakh, Sonam, et al.
Publicado: (2015)

Protein disulphide isomerase can predict the clinical prognostic value and contribute to malignant progression in gliomas
por: Hu, Qing, et al.
Publicado: (2020)

Pathological consequences of the unfolded protein response and downstream protein disulphide isomerases in pulmonary viral infection and disease
por: Chamberlain, Nicolas, et al.
Publicado: (2020)

Male-Specific Protein Disulphide Isomerase Function is Essential for Plasmodium Transmission and a Vulnerable Target for Intervention
por: Angrisano, Fiona, et al.
Publicado: (2019)

ER stress and unfolded protein response in amyotrophic lateral sclerosis—a controversial role of protein disulphide isomerase
por: Jaronen, Merja, et al.
Publicado: (2014)

Therapeutic potential of targeting protein for Xklp2 silencing for pancreatic cancer
por: Miwa, Tomohiro, et al.
Publicado: (2015)

BCR‐ABL enhances the prolyl isomerase activity of Pin 1 by interacting with DAPK1 in ph(+) ALL
por: Cao, Wen‐bin, et al.
Publicado: (2018)

Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc
por: Aird, Fraser, et al.
Publicado: (2017)

Hydrogen sulphide reduces hyperhomocysteinaemia‐induced endothelial ER stress by sulfhydrating protein disulphide isomerase to attenuate atherosclerosis
por: Jiang, Shan, et al.
Publicado: (2021)

Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in gliomas
por: Ulasov, Ilya, et al.
Publicado: (2013)

Ovarian cancer: Current status and strategies for improving therapeutic outcomes
por: Chandra, Ashwin, et al.
Publicado: (2019)

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
por: Clarke, Paul A, et al.
Publicado: (2016)

Protein Disulphide Isomerase and NADPH Oxidase 1 Cooperate to Control Platelet Function and Are Associated with Cardiometabolic Disease Risk Factors
por: Gaspar, Renato Simões, et al.
Publicado: (2021)

Protein Disulphide Isomerase A1 Is Involved in the Regulation of Breast Cancer Cell Adhesion and Transmigration via Lung Microvascular Endothelial Cells
por: Stojak, Marta, et al.
Publicado: (2020)

The failure to express a protein disulphide isomerase-like protein results in a floury endosperm and an endoplasmic reticulum stress response in rice
por: Han, Xiaohua, et al.
Publicado: (2012)

Protein disulphide isomerase (PDI) is protective against amyotrophic lateral sclerosis (ALS)-related mutant Fused in Sarcoma (FUS) in in vitro models
por: Parakh, S., et al.
Publicado: (2021)

Molecular docking‐assisted screening reveals tannic acid as a natural protein disulphide isomerase inhibitor with antiplatelet and antithrombotic activities
por: Ren, Lijie, et al.
Publicado: (2020)

Clathrin‐mediated EGFR endocytosis as a potential therapeutic strategy for overcoming primary resistance of EGFR TKI in wild‐type EGFR non‐small cell lung cancer
por: Kim, Boyeon, et al.
Publicado: (2020)

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
por: Whitton, Bradleigh, et al.
Publicado: (2018)

Comparison of anti-cancer effects of novel protein disulphide isomerase (PDI) inhibitors in breast cancer cells characterized by high and low PDIA17 expression
por: Kurpińska, Anna, et al.
Publicado: (2022)

The ‘Shape-Shifter’ Peptide from the Disulphide Isomerase PmScsC Shows Context-Dependent Conformational Preferences
por: Smith, Lorna J., et al.
Publicado: (2021)

ITGB4 as a novel serum diagnosis biomarker and potential therapeutic target for colorectal cancer
por: Jiang, Xia, et al.
Publicado: (2021)

Comprehensive genomic profiling of small cell lung cancer in Chinese patients and the implications for therapeutic potential
por: Hu, Jing, et al.
Publicado: (2019)

Reversal of Alpha-Synuclein Fibrillization by Protein Disulfide Isomerase
por: Serrano, Albert, et al.
Publicado: (2020)

A disulphide isomerase gene (PDI-V) from Haynaldia villosa contributes to powdery mildew resistance in common wheat
por: Faheem, Muhammad, et al.
Publicado: (2016)

Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer
por: Theard, Patricia L, et al.
Publicado: (2020)

Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers
por: Vinet, Mathilde, et al.
Publicado: (2019)

Maternal embryonic leucine zipper kinase: A novel biomarker and a potential therapeutic target of cervical cancer
por: Wang, Juan, et al.
Publicado: (2018)

Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer
por: Dayan, Dan, et al.
Publicado: (2012)

Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells
por: Sato, Naoki, et al.
Publicado: (2015)

A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes
por: Syed, Farooq, et al.
Publicado: (2022)

(19)F NMR spectroscopy monitors ligand binding to recombinantly fluorine-labelled b′x from human protein disulphide isomerase (hPDI)
por: Curtis-Marof, Rose, et al.
Publicado: (2014)

Therapeutic potential of CRISPR/Cas9 gene editing in engineered T‐cell therapy
por: Gao, Qianqian, et al.
Publicado: (2019)

Proteomic profiling of FBXW7‐mutant serous endometrial cancer cells reveals upregulation of PADI2, a potential therapeutic target
por: Urick, Mary Ellen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_msd1tq3jpp3fp2eab7m9javbeu