Insulin Resistance and Pellino-1 Mediated Decrease in the Activities of Vasodilator Signaling Contributes to Sunitinib-Induced Hypertension

Antiangiogenic tyrosine kinases inhibitors induce hypertension, which may increase the incidents of cardiovascular complications and limit their use. However, the mechanisms by which usage of TKIs results in hypertension have not been fully understood. Here, we report the potential mechanisms of how...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Tang, Liang-Liang, Liang, Chen, Wu, Ming-Ming, Zhang, Zhi-Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027079/
https://www.ncbi.nlm.nih.gov/pubmed/33841146
http://dx.doi.org/10.3389/fphar.2021.617165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027079/
https://www.ncbi.nlm.nih.gov/pubmed/33841146
http://dx.doi.org/10.3389/fphar.2021.617165

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