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Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors
Proinsulin is an abundant protein that is selectively expressed by pancreatic beta cells and has been a focus for development of antigen-specific immunotherapies for type 1 diabetes (T1D). In this study, we sought to comprehensively evaluate reactivity to preproinsulin by CD4 T cells originally isol...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027116/ https://www.ncbi.nlm.nih.gov/pubmed/33841327 http://dx.doi.org/10.3389/fendo.2021.622647 |