A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis

Streptoseomycin (STM, 1) is a bacterial macrolactone that has a unique 5/14/10/6/6-pentacyclic ring with an ether bridge. We have previously identified the biosynthetic gene cluster for 1 and characterized StmD as [6 + 4]- and [4 + 2]-bispericyclase that catalyze a reaction leading to both 6/10/6- a...

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Detalles Bibliográficos
Autores principales: Wang, Kai Biao, Wang, Wen, Zhang, Bo, Wang, Xin, Chen, Yu, Zhu, Hong Jie, Liang, Yong, Tan, Ren Xiang, Ge, Hui Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027225/
https://www.ncbi.nlm.nih.gov/pubmed/33828077
http://dx.doi.org/10.1038/s41467-021-22395-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027225/
https://www.ncbi.nlm.nih.gov/pubmed/33828077
http://dx.doi.org/10.1038/s41467-021-22395-7

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