Schiff-Linked PEGylated Doxorubicin Prodrug Forming pH-Responsive Nanoparticles With High Drug Loading and Effective Anticancer Therapy

Developing efficacious drug delivery systems for targeted cancer chemotherapy remains a major challenge. Here we demonstrated a kind of pH-responsive PEGylated doxorubicin (DOX) prodrug via the effective esterification and Schiff base reactions, which could self-assemble into the biodegradable micel...

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Detalles Bibliográficos
Autores principales: Song, Jian, Xu, Bingbing, Yao, Hui, Lu, Xiaofang, Tan, Yang, Wang, Bingyang, Wang, Xing, Yang, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027505/
https://www.ncbi.nlm.nih.gov/pubmed/33842372
http://dx.doi.org/10.3389/fonc.2021.656717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027505/
https://www.ncbi.nlm.nih.gov/pubmed/33842372
http://dx.doi.org/10.3389/fonc.2021.656717

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