ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation

Motor neurons (MNs) are highly energetic cells and recent studies suggest that altered energy metabolism precede MN loss in amyotrophic lateral sclerosis (ALS), an age-onset neurodegenerative disease. However, clear mechanistic insights linking altered metabolism and MN death are still missing. In t...

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Detalles Bibliográficos
Autores principales: Hor, Jin-Hui, Santosa, Munirah Mohamad, Lim, Valerie Jing Wen, Ho, Beatrice Xuan, Taylor, Amy, Khong, Zi Jian, Ravits, John, Fan, Yong, Liou, Yih-Cherng, Soh, Boon-Seng, Ng, Shi-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027637/
https://www.ncbi.nlm.nih.gov/pubmed/33184465
http://dx.doi.org/10.1038/s41418-020-00664-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027637/
https://www.ncbi.nlm.nih.gov/pubmed/33184465
http://dx.doi.org/10.1038/s41418-020-00664-0

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