Cargando…
ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation
Motor neurons (MNs) are highly energetic cells and recent studies suggest that altered energy metabolism precede MN loss in amyotrophic lateral sclerosis (ALS), an age-onset neurodegenerative disease. However, clear mechanistic insights linking altered metabolism and MN death are still missing. In t...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027637/ https://www.ncbi.nlm.nih.gov/pubmed/33184465 http://dx.doi.org/10.1038/s41418-020-00664-0 |