Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes

Mitochondria harbor a unique fatty acid synthesis pathway (mtFAS) with mysterious functions gaining increasing interest, while its involvement in metabolic regulation is essentially unknown. Here we show that 3-Hydroxyacyl-ACP dehydratase (HTD2), a key enzyme in mtFAS pathway was primarily downregul...

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Detalles Bibliográficos
Autores principales: Zeng, Mengqi, Xu, Jie, Zhang, Zhengyi, Zou, Xuan, Wang, Xueqiang, Cao, Ke, Lv, Weiqiang, Cui, Yuting, Long, Jiangang, Feng, Zhihui, Liu, Jiankang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027779/
https://www.ncbi.nlm.nih.gov/pubmed/33774475
http://dx.doi.org/10.1016/j.redox.2021.101948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027779/
https://www.ncbi.nlm.nih.gov/pubmed/33774475
http://dx.doi.org/10.1016/j.redox.2021.101948

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