Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis

SapM is a secreted virulence factor from Mycobacterium tuberculosis critical for pathogen survival and persistence inside the host. Its full potential as a target for tuberculosis treatment has not yet been exploited because of the lack of potent inhibitors available. By screening over 1500 small mo...

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Detalles Bibliográficos
Autores principales: Fernández-Soto, Paulina, Casulli, Joshua, Solano-Castro, Danilo, Rodríguez-Fernández, Pablo, Jowitt, Thomas A., Travis, Mark A., Cavet, Jennifer S., Tabernero, Lydia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027839/
https://www.ncbi.nlm.nih.gov/pubmed/33828158
http://dx.doi.org/10.1038/s41598-021-87117-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027839/
https://www.ncbi.nlm.nih.gov/pubmed/33828158
http://dx.doi.org/10.1038/s41598-021-87117-x

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