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Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners
The Mre11-Rad50-Xrs2 (MRX) complex detects and processes DNA double-strand breaks (DSBs). Its DNA binding and processing activities are regulated by transitions between an ATP-bound state and a post-hydrolysis cutting state that is nucleolytically active. Mre11 endonuclease activity is stimulated by...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8028314/ https://www.ncbi.nlm.nih.gov/pubmed/33789097 http://dx.doi.org/10.1016/j.celrep.2021.108906 |