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Structure-based Design of a Specific, Homogeneous Luminescence Enzyme Reporter Assay for SARS-CoV-2

Recombinant antibodies (Abs) against the SARS-CoV-2 virus hold promise for treatment of COVID-19 and high sensitivity and specific diagnostic assays. Here, we report engineering principles and realization of a Protein-fragment Complementation Assay (PCA) detector of SARS-CoV-2 antigen by coupling tw...

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Detalles Bibliográficos
Autores principales: Fellouse, Frederic A., Miersch, Shane, Chen, Chao, Michnick, Stephen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8028696/
https://www.ncbi.nlm.nih.gov/pubmed/33839165
http://dx.doi.org/10.1016/j.jmb.2021.166983