High-resolution structures of the SARS-CoV-2 2’-O-methyltransferase reveal strategies for structure-based inhibitor design

There are currently no antiviral therapies specific for SARS-CoV-2, the virus responsible for the global pandemic disease COVID-19. To facilitate structure-based drug design, we conducted an X-ray crystallographic study of the SARS-CoV-2 nsp16-nsp10 2′-O-methyltransferase complex, which methylates C...

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Detalles Bibliográficos
Autores principales: Rosas-Lemus, Monica, Minasov, George, Shuvalova, Ludmilla, Inniss, Nicole, Kiryukhina, Olga, Brunzelle, Joseph, Satchell, Karla J. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8028745/
https://www.ncbi.nlm.nih.gov/pubmed/32994211
http://dx.doi.org/10.1126/scisignal.abe1202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8028745/
https://www.ncbi.nlm.nih.gov/pubmed/32994211
http://dx.doi.org/10.1126/scisignal.abe1202

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