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A Multi-Omics Analysis of Metastatic Melanoma Identifies a Germinal Center-Like Tumor Microenvironment in HLA-DR-Positive Tumor Areas

The emergence of immune checkpoint inhibitors has dramatically changed the therapeutic landscape for patients with advanced melanoma. However, relatively low response rates and a high incidence of severe immune-related adverse events have prompted the search for predictive biomarkers. A positive pre...

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Detalles Bibliográficos
Autores principales: Gadeyne, Laura, Van Herck, Yannick, Milli, Giorgia, Atak, Zeynep Kalender, Bolognesi, Maddalena Maria, Wouters, Jasper, Marcelis, Lukas, Minia, Angeliki, Pliaka, Vaia, Roznac, Jan, Alexopoulos, Leonidas G., Cattoretti, Giorgio, Bechter, Oliver, Oord, Joost Van Den, De Smet, Frederik, Antoranz, Asier, Bosisio, Francesca Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8029980/
https://www.ncbi.nlm.nih.gov/pubmed/33842341
http://dx.doi.org/10.3389/fonc.2021.636057