Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke
Substantial behavioral evidence implies the existence of separable working memory (WM) components for maintaining phonological and semantic information. In contrast, only a few studies have addressed the neural basis of phonological versus semantic WM using functional neuroimaging and none has used...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030664/ https://www.ncbi.nlm.nih.gov/pubmed/33870195 http://dx.doi.org/10.1093/texcom/tgab005 |
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author | Martin, Randi C Ding, Junhua Hamilton, A Cris Schnur, Tatiana T |
author_facet | Martin, Randi C Ding, Junhua Hamilton, A Cris Schnur, Tatiana T |
author_sort | Martin, Randi C |
collection | PubMed |
description | Substantial behavioral evidence implies the existence of separable working memory (WM) components for maintaining phonological and semantic information. In contrast, only a few studies have addressed the neural basis of phonological versus semantic WM using functional neuroimaging and none has used a lesion-symptom mapping (LSM) approach. Here, we address this gap, reporting a multivariate LSM study of phonological and semantic WM for 94 individuals at the acute stage of left hemisphere stroke. Testing at the acute stage avoids issues of brain reorganization and the adoption of patient strategies for task performance. The LSM analyses for each WM component controlled for the other WM component and semantic and phonological knowledge at the single word level. For phonological WM, the regions uncovered included the supramarginal gyrus, argued to be the site of phonological storage, and several cortical and subcortical regions plausibly related to inner rehearsal. For semantic WM, inferior frontal regions and the angular gyrus were uncovered. The findings thus provide converging evidence for separable systems for phonological and semantic WM that are distinguished from the systems supporting long-term knowledge representations in those domains. |
format | Online Article Text |
id | pubmed-8030664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-80306642021-04-14 Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke Martin, Randi C Ding, Junhua Hamilton, A Cris Schnur, Tatiana T Cereb Cortex Commun Original Article Substantial behavioral evidence implies the existence of separable working memory (WM) components for maintaining phonological and semantic information. In contrast, only a few studies have addressed the neural basis of phonological versus semantic WM using functional neuroimaging and none has used a lesion-symptom mapping (LSM) approach. Here, we address this gap, reporting a multivariate LSM study of phonological and semantic WM for 94 individuals at the acute stage of left hemisphere stroke. Testing at the acute stage avoids issues of brain reorganization and the adoption of patient strategies for task performance. The LSM analyses for each WM component controlled for the other WM component and semantic and phonological knowledge at the single word level. For phonological WM, the regions uncovered included the supramarginal gyrus, argued to be the site of phonological storage, and several cortical and subcortical regions plausibly related to inner rehearsal. For semantic WM, inferior frontal regions and the angular gyrus were uncovered. The findings thus provide converging evidence for separable systems for phonological and semantic WM that are distinguished from the systems supporting long-term knowledge representations in those domains. Oxford University Press 2021-01-28 /pmc/articles/PMC8030664/ /pubmed/33870195 http://dx.doi.org/10.1093/texcom/tgab005 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Martin, Randi C Ding, Junhua Hamilton, A Cris Schnur, Tatiana T Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke |
title | Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke |
title_full | Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke |
title_fullStr | Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke |
title_full_unstemmed | Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke |
title_short | Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke |
title_sort | working memory capacities neurally dissociate: evidence from acute stroke |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030664/ https://www.ncbi.nlm.nih.gov/pubmed/33870195 http://dx.doi.org/10.1093/texcom/tgab005 |
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