Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke

Substantial behavioral evidence implies the existence of separable working memory (WM) components for maintaining phonological and semantic information. In contrast, only a few studies have addressed the neural basis of phonological versus semantic WM using functional neuroimaging and none has used...

Descripción completa

Detalles Bibliográficos
Autores principales: Martin, Randi C, Ding, Junhua, Hamilton, A Cris, Schnur, Tatiana T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030664/
https://www.ncbi.nlm.nih.gov/pubmed/33870195
http://dx.doi.org/10.1093/texcom/tgab005
_version_ 1783676123243085824
author Martin, Randi C
Ding, Junhua
Hamilton, A Cris
Schnur, Tatiana T
author_facet Martin, Randi C
Ding, Junhua
Hamilton, A Cris
Schnur, Tatiana T
author_sort Martin, Randi C
collection PubMed
description Substantial behavioral evidence implies the existence of separable working memory (WM) components for maintaining phonological and semantic information. In contrast, only a few studies have addressed the neural basis of phonological versus semantic WM using functional neuroimaging and none has used a lesion-symptom mapping (LSM) approach. Here, we address this gap, reporting a multivariate LSM study of phonological and semantic WM for 94 individuals at the acute stage of left hemisphere stroke. Testing at the acute stage avoids issues of brain reorganization and the adoption of patient strategies for task performance. The LSM analyses for each WM component controlled for the other WM component and semantic and phonological knowledge at the single word level. For phonological WM, the regions uncovered included the supramarginal gyrus, argued to be the site of phonological storage, and several cortical and subcortical regions plausibly related to inner rehearsal. For semantic WM, inferior frontal regions and the angular gyrus were uncovered. The findings thus provide converging evidence for separable systems for phonological and semantic WM that are distinguished from the systems supporting long-term knowledge representations in those domains.
format Online
Article
Text
id pubmed-8030664
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-80306642021-04-14 Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke Martin, Randi C Ding, Junhua Hamilton, A Cris Schnur, Tatiana T Cereb Cortex Commun Original Article Substantial behavioral evidence implies the existence of separable working memory (WM) components for maintaining phonological and semantic information. In contrast, only a few studies have addressed the neural basis of phonological versus semantic WM using functional neuroimaging and none has used a lesion-symptom mapping (LSM) approach. Here, we address this gap, reporting a multivariate LSM study of phonological and semantic WM for 94 individuals at the acute stage of left hemisphere stroke. Testing at the acute stage avoids issues of brain reorganization and the adoption of patient strategies for task performance. The LSM analyses for each WM component controlled for the other WM component and semantic and phonological knowledge at the single word level. For phonological WM, the regions uncovered included the supramarginal gyrus, argued to be the site of phonological storage, and several cortical and subcortical regions plausibly related to inner rehearsal. For semantic WM, inferior frontal regions and the angular gyrus were uncovered. The findings thus provide converging evidence for separable systems for phonological and semantic WM that are distinguished from the systems supporting long-term knowledge representations in those domains. Oxford University Press 2021-01-28 /pmc/articles/PMC8030664/ /pubmed/33870195 http://dx.doi.org/10.1093/texcom/tgab005 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Martin, Randi C
Ding, Junhua
Hamilton, A Cris
Schnur, Tatiana T
Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke
title Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke
title_full Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke
title_fullStr Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke
title_full_unstemmed Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke
title_short Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke
title_sort working memory capacities neurally dissociate: evidence from acute stroke
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030664/
https://www.ncbi.nlm.nih.gov/pubmed/33870195
http://dx.doi.org/10.1093/texcom/tgab005
work_keys_str_mv AT martinrandic workingmemorycapacitiesneurallydissociateevidencefromacutestroke
AT dingjunhua workingmemorycapacitiesneurallydissociateevidencefromacutestroke
AT hamiltonacris workingmemorycapacitiesneurallydissociateevidencefromacutestroke
AT schnurtatianat workingmemorycapacitiesneurallydissociateevidencefromacutestroke