Targeted mutagenesis on PDGFRα-Fc identifies amino acid modifications that allow efficient inhibition of HCMV infection while abolishing PDGF sequestration

Platelet-derived growth factor receptor alpha (PDGFRα) serves as an entry receptor for the human cytomegalovirus (HCMV), and soluble PDGFRα-Fc can neutralize HCMV at a half-maximal effective concentration (EC50) of about 10 ng/ml. While this indicates a potential for usage as an HCMV entry inhibitor...

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Detalles Bibliográficos
Autores principales: Feldmann, Svenja, Grimm, Immanuel, Stöhr, Dagmar, Antonini, Chiara, Lischka, Peter, Sinzger, Christian, Stegmann, Cora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031885/
https://www.ncbi.nlm.nih.gov/pubmed/33780515
http://dx.doi.org/10.1371/journal.ppat.1009471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031885/
https://www.ncbi.nlm.nih.gov/pubmed/33780515
http://dx.doi.org/10.1371/journal.ppat.1009471

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