Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing

BACKGROUND: TTN (Titin), the largest protein in humans, forms the molecular spring that spans half of the sarcomere to provide passive elasticity to the cardiomyocyte. Mutations that disrupt the TTN transcript are the most frequent cause of hereditary heart failure. We showed before that TTN produce...

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Detalles Bibliográficos
Autores principales: Tijsen, Anke J., Cócera Ortega, Lucía, Reckman, Yolan J., Zhang, Xiaolei, van der Made, Ingeborg, Aufiero, Simona, Li, Jiuru, Kamps, Selina C., van den Bout, Anouk, Devalla, Harsha D., van Spaendonck-Zwarts, Karin Y., Engelhardt, Stefan, Gepstein, Lior, Ware, James S., Pinto, Yigal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032209/
https://www.ncbi.nlm.nih.gov/pubmed/33583186
http://dx.doi.org/10.1161/CIRCULATIONAHA.120.050455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032209/
https://www.ncbi.nlm.nih.gov/pubmed/33583186
http://dx.doi.org/10.1161/CIRCULATIONAHA.120.050455

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