Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor

Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on the N-terminal tails of histones through two bromodomains (BD1 and BD2) to regulate gene transcription. Inhibiting one or both of bromodomains resulted in different phenotypes, suggesting BD1 and BD2 may have different funct...

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Detalles Bibliográficos
Autores principales: Li, Jiao, Zou, Wei, Yu, Koukou, Liu, Bing, Liang, Weifeng, Wang, Lisha, Lu, Yin, Jiang, Zequn, Wang, Aiyun, Zhu, Jiapeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032343/
https://www.ncbi.nlm.nih.gov/pubmed/33820450
http://dx.doi.org/10.1080/14756366.2021.1906663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032343/
https://www.ncbi.nlm.nih.gov/pubmed/33820450
http://dx.doi.org/10.1080/14756366.2021.1906663

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