Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers

Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers. However, not all patients respond due to intrinsic or acquired resistance to PARP1 inhibitor. Development of alternative synthetic lethality app...

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Detalles Bibliográficos
Autores principales: Ali, Reem, Alblihy, Adel, Miligy, Islam M., Alabdullah, Muslim L., Alsaleem, Mansour, Toss, Michael S., Algethami, Mashael, Abdel-Fatah, Tarek, Moseley, Paul, Chan, Stephen, Mongan, Nigel P., Narayan, Satya, Rakha, Emad A., Madhusudan, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032555/
https://www.ncbi.nlm.nih.gov/pubmed/33674744
http://dx.doi.org/10.1038/s41388-021-01710-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032555/
https://www.ncbi.nlm.nih.gov/pubmed/33674744
http://dx.doi.org/10.1038/s41388-021-01710-y

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