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Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers

Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers. However, not all patients respond due to intrinsic or acquired resistance to PARP1 inhibitor. Development of alternative synthetic lethality app...

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Detalles Bibliográficos
Autores principales:	Ali, Reem, Alblihy, Adel, Miligy, Islam M., Alabdullah, Muslim L., Alsaleem, Mansour, Toss, Michael S., Algethami, Mashael, Abdel-Fatah, Tarek, Moseley, Paul, Chan, Stephen, Mongan, Nigel P., Narayan, Satya, Rakha, Emad A., Madhusudan, Srinivasan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032555/ https://www.ncbi.nlm.nih.gov/pubmed/33674744 http://dx.doi.org/10.1038/s41388-021-01710-y

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