The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro

A major challenge in current cancer therapy is still the treatment of metastatic melanomas of the skin. BH3 mimetics represent a novel group of substances inducing apoptosis. In this study, we investigated the cytotoxic effect of (±) gossypol (GP), a natural compound from cotton seed, on A375 melano...

Descripción completa

Detalles Bibliográficos
Autores principales: Haasler, Lisa, Kondadi, Arun Kumar, Tsigaras, Thanos, von Montfort, Claudia, Graf, Peter, Stahl, Wilhelm, Brenneisen, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Molecular Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032633/
https://www.ncbi.nlm.nih.gov/pubmed/33523262
http://dx.doi.org/10.1007/s00204-021-02987-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032633/
https://www.ncbi.nlm.nih.gov/pubmed/33523262
http://dx.doi.org/10.1007/s00204-021-02987-4

Ejemplares similares