Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand

When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose homeostasis. The role that growth control genes, highly expressed in early pancreas development, might exert in programming β-cell plasticity in later life is a poorly stu...

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Detalles Bibliográficos
Autores principales: Sandovici, Ionel, Hammerle, Constanze M., Virtue, Sam, Vivas-Garcia, Yurena, Izquierdo-Lahuerta, Adriana, Ozanne, Susan E., Vidal-Puig, Antonio, Medina-Gómez, Gema, Constância, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032793/
https://www.ncbi.nlm.nih.gov/pubmed/33833312
http://dx.doi.org/10.1038/s41598-021-87292-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032793/
https://www.ncbi.nlm.nih.gov/pubmed/33833312
http://dx.doi.org/10.1038/s41598-021-87292-x

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