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The Enigma of Substrate Recognition and Catalytic Efficiency of APE1-Like Enzymes

Despite significant achievements in the elucidation of the nature of protein-DNA contacts that control the specificity of nucleotide incision repair (NIR) by apurinic/apyrimidinic (AP) endonucleases, the question on how a given nucleotide is accommodated by the active site of the enzyme remains unan...

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Detalles Bibliográficos
Autores principales:	Davletgildeeva, Anastasiia T., Ishchenko, Alexander A., Saparbaev, Murat, Fedorova, Olga S., Kuznetsov, Nikita A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033172/ https://www.ncbi.nlm.nih.gov/pubmed/33842455 http://dx.doi.org/10.3389/fcell.2021.617161

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