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Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors
Despite considerable efforts, therapeutic strategies targeting the Wnt pathway are still not clinically available. The pervasive role of Wnt‐βcatenin signaling for the control of stem cells during normal tissue homeostasis makes the on‐target toxicity of available therapeutic grade molecules an impo...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033510/ https://www.ncbi.nlm.nih.gov/pubmed/33787008 http://dx.doi.org/10.15252/emmm.202114002 |