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The enhancement of activity rescues the establishment of Mecp2 null neuronal phenotypes

MECP2 mutations cause Rett syndrome (RTT), a severe and progressive neurodevelopmental disorder mainly affecting females. Although RTT patients exhibit delayed onset of symptoms, several evidences demonstrate that MeCP2 deficiency alters early development of the brain. Indeed, during early maturatio...

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Detalles Bibliográficos
Autores principales: Scaramuzza, Linda, De Rocco, Giuseppina, Desiato, Genni, Cobolli Gigli, Clementina, Chiacchiaretta, Martina, Mirabella, Filippo, Pozzi, Davide, De Simone, Marco, Conforti, Paola, Pagani, Massimiliano, Benfenati, Fabio, Cesca, Fabrizia, Bedogni, Francesco, Landsberger, Nicoletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033520/
https://www.ncbi.nlm.nih.gov/pubmed/33665914
http://dx.doi.org/10.15252/emmm.202012433