Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters

[Image: see text] Missense mutations that give rise to protein misfolding are rare, but collectively, defective protein folding diseases are consequential. Folding deficiencies are amenable to pharmacological correction (pharmacochaperoning), but the underlying mechanisms remain enigmatic. Ibogaine...

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Detalles Bibliográficos
Autores principales: Bhat, Shreyas, Guthrie, Daryl A., Kasture, Ameya, El-Kasaby, Ali, Cao, Jianjing, Bonifazi, Alessandro, Ku, Therese, Giancola, JoLynn B., Hummel, Thomas, Freissmuth, Michael, Newman, Amy Hauck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033614/
https://www.ncbi.nlm.nih.gov/pubmed/33860180
http://dx.doi.org/10.1021/acsptsci.0c00102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033614/
https://www.ncbi.nlm.nih.gov/pubmed/33860180
http://dx.doi.org/10.1021/acsptsci.0c00102

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